Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers

Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA). We investigated the impact of the linoleic acid (LA) intake on AA levels in humans. Methods: Six healthy female volunteers (age range 2334 years) were given liquid formula diets (LFD) devoid of AA for 6 weeks, providing a constant intake of zero energy% (LFD 0: protein 15%, carbohydrates 85%) or 20 energy% (LFD 20: protein 15%, carbohydrates 55%, fat 30%) LA, for 3 weeks each. Fatty acids of plasma cholesteryl esters and platelet lipids were determined each week, and the prostaglandin biosynthesis was measured in 24-hour urine samples. Results: LFD 0 increased (+31% of initial value) and LFD 20 lowered (-30% of initial value) the percentage of AA in plasma cholesteryl esters and platelet lipids. Moreover, absence of dietary AA lowered the percentages of AA in plasma (-31% week 0 vs. week 6) and platelet (-11%) lipids, indicating a low transformation of LA. LFD 0 reduced urinary metabolite levels of prostaglandins D, E, and F in 24-hour urine samples (-48%, p < 0.001) within 24 h, but did not significantly affect platelet aggregation (-10%) and thromboxane formation (-25%). LFD 20 significantly lowered platelet aggregation (-25%) and thromboxane formation (-43%). The prostaglandin metabolite levels increased during the first 10 days, declined thereafter, and were lower than the preexperimental values at the end of the 3-week period. Conclusions: The results show that dietary LA does not increase the AA levels in plasma or platelet lipids and does not persistently contribute to prostaglandin biosynthesis which is increased by AA intake with Western diets

Modelling and simulation of rail passengers to evaluate methods to reduce dwell times

The paper outlines a feasibility study using modelling and simulation to reduce dwell times and increase rail network capacity. We use agent based modelling, where passengers are treated as a separate entities, basing their movements on rules from the Social Force Model (SFM), proposed by Helbing to model pedestrian dynamics. Implementing this SFM, together with a novel decision making system for passengers' door choices, a mesoscopic model is produced of the platform, train and passengers. An outline of the modelling process is presented, along with a critical analysis of the final model. Analyses are conducted to evaluate novel concepts in train and platform design, to reduce loading times, using passengers with a range of attributes. In a simulation experiment, four concepts (wider doors, designated boarding/alighting doors, and an active passenger information system) are assessed, with the latter two giving reductions in loading times of 7.0% and 7.3%

Leveraging Mathematical Subject Information to Enhance Bibliometric Data

The field of mathematics is known to be especially challenging from a bibliometric point of view. Its bibliographic metrics are especially sensitive to distortions and are heavily influenced by the subject and its popularity. Therefore, quantitative methods are prone to misrepresentations, and need to take subject information into account. In this paper we investigate how the mathematical bibliography of the abstracting and reviewing service Zentralblatt MATH (zbMATH) could further benefit from the inclusion of mathematical subject information MSC2010. Furthermore, the mappings of MSC2010 to Linked Open Data resources have been upgraded and extended to also benefit from semantic information provided by DBpedia

On Temporal References in Emergent Communication

As humans, we use linguistic elements referencing time, such as before or tomorrow, to easily share past experiences and future predictions. While temporal aspects of the language have been considered in computational linguistics, no such exploration has been done within the field of emergent communication. We research this gap, providing the first reported temporal vocabulary within emergent communication literature. Our experimental analysis shows that a different agent architecture is sufficient for the natural emergence of temporal references, and that no additional losses are necessary. Our readily transferable architectural insights provide the basis for the incorporation of temporal referencing into other emergent communication environments.Comment: 26 pages, 13 figures. Code available at https://anonymous.4open.science/r/TRG-E137/README.m

Implementing Network Virtualization for a Future Internet

Abstract — The Internet has become an essential communication medium upon which billions of people rely every day. However, necessary evolution of the Internet has been severely limited by reliability constrains and social-economic factors. Experts fear that current growth rates will threaten the future of the Internet as a whole, despite the fact that new core technologies already exist. Network virtualization presents a promising approach to overcome ossification and facilitate service deployment for a future Internet. Exploring this approach, we present a prototype implementation which realizes a subset of the 4WARD virtual network (VNet) architecture, allowing multiple VNets to coexist on top of a shared physical infrastructure. We discuss the functionality of our prototype and demonstrate experimental results to assess its performance. I

Maine’s Winter Roads: Salt, Safety, Environment and Cost

This report summarizes key findings from a yearlong study of the issues and practices in winter maintenance of Maine’s roads

Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington’s disease

Altered neuronal activity in the striatum appears to be a key component of Huntington’s disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity of striatal neurons. We found that relative to wild-type controls, HD rats suffer from population-level deficits in striatal activity characterized by a loss of correlated firing and fewer episodes of coincident spike bursting between simultaneously recorded neuronal pairs. These results are in line with our previous report of marked alterations in the pattern of striatal firing in mouse models of HD that vary in background strain, genetic construct, and symptom severity. Thus, loss of coordinated spike activity in striatum appears to be a common feature of HD pathophysiology, regardless of HD model variability

Recursive Definitions of Monadic Functions

Using standard domain-theoretic fixed-points, we present an approach for defining recursive functions that are formulated in monadic style. The method works both in the simple option monad and the state-exception monad of Isabelle/HOL's imperative programming extension, which results in a convenient definition principle for imperative programs, which were previously hard to define. For such monadic functions, the recursion equation can always be derived without preconditions, even if the function is partial. The construction is easy to automate, and convenient induction principles can be derived automatically.Comment: In Proceedings PAR 2010, arXiv:1012.455

Cell atlas of the Atlantic salmon spleen reveals immune cell heterogeneity and cellspecific responses to bacterial infection

The spleen is a conserved secondary lymphoid organ that emerged in parallel to adaptive immunity in early jawed vertebrates. Recent studies have applied single cell transcriptomics to reveal the cellular composition of spleen in several species, cataloguing diverse immune cell types and subpopulations.In this study, 51,119 spleen nuclei transcriptomes were comprehensively investigated in the commercially important teleost Atlantic salmon (Salmo salar L.), contrasting control animals with those challenged with the bacterial pathogen Aeromonas salmonicida. We identified clusters of nuclei representing the expected major cell types, namely T cells, B cells, natural killer-like cells, granulocytes, mononuclear phagocytes, endothelial cells, mesenchymal cells, erythrocytes and thrombocytes. We discovered heterogeneity within several immune lineages, providing evidence for resident macrophages and melanomacrophages, infiltrating monocytes, several candidate dendritic cell subpopulations, and B cells at distinct stages of differentiation, including plasma cells and an igt+ subset. We provide evidence for twelve candidate T cell subsets, including cd4+ T helper and regulatory T cells, one cd8+ subset, three γδT subsets, and populations double negative for cd4 and cd8. The number of genes showing differential expression during the early stages of Aeromonas infection was highly variable across immune cell types, with the largest changes observed in macrophages and infiltrating monocytes, followed by resting mature B cells. Our analysis provides evidence for a local inflammatory response to infection alongside B cell maturation in the spleen, and upregulation of ccr9 genes in igt+ B cells, T helper and cd8+ cells, and monocytes, consistent with the recruitment of immune cell populations to the gut to deal with Aeromonas infection. Overall, this study provides a new cell-resolved perspective of the immune actions of Atlantic salmon spleen, highlighting extensive heterogeneity hidden to bulk transcriptomics. We further provide a large catalogue of cell-specific marker genes that can be leveraged to further explore the function and structural organization of the salmonid immune system